(9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one and Pharyngitis

The effects of a dose of beclomethasone inhaler (50 micrograms) or lidocaine 10% spray on postoperative sore throat were studied in 120 patients undergoing tracheal intubation for elective surgical procedures. Fifty-four patients (90%) in the beclomethasone group scored no postoperative sore throat compared with 27 (45%) in the lidocaine group (P < 0.001). Beclomethasone inhaler seems to be highly effective in the prevention of postoperative sore throat and is therefore to be recommended before tracheal intubation for general anaesthesia.

Topics: Adult; Aerosols; Aged; Analgesics; Anesthesia, General; Beclomethasone; Cough; Female; Humans; Incidence; Intubation, Intratracheal; Lidocaine; Male; Middle Aged; Nebulizers and Vaporizers; Pharyngitis; Time Factors

Topics: Administration, Oral; Administration, Topical; Adrenal Insufficiency; Aerosols; Anti-Inflammatory Agents; Asthma; Beclomethasone; Clinical Trials as Topic; Glucocorticoids; Humans; Pharyngitis; Placebos; Prednisone; Respiratory Function Tests; Respiratory Tract Infections; Rhinitis, Allergic, Seasonal; Substance Withdrawal Syndrome; Substance-Related Disorders

We compared the incidence of Candida infection, Candida colonization, and reduction in oral prednisone dose in patients with asthma treated with beclomethasone dipropionate delivered by metered-dose inhaler (MDI) alone and MDI plus Aerochamber. Group M contained 18 patients treated with beclomethasone, four actuations four times a day (672 micrograms/day), delivered by MDI alone. Group A contained 18 patients treated with the same dose of beclomethasone delivered by MDI plus Aerochamber. In group M, four of 18 patients had Candida infection, 12 of 18 patients had Candida colonization, and six of 18 patients were completely removed from oral prednisone. In group A, 0 of 18 patients had Candida infection (p = 0.05), six of 18 patients had Candida colonization (p less than 0.05), and 12 of 18 patients were completely removed from oral prednisone (p less than 0.05). We conclude that beclomethasone delivered by MDI plus Aerochamber is more efficacious in reducing oral prednisone dependency and produces less Candida infection and colonization than beclomethasone delivered by MDI alone.

Topics: Administration, Oral; Adult; Aerosol Propellants; Aerosols; Asthma; Beclomethasone; Candidiasis, Oral; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Nebulizers and Vaporizers; Pharyngitis; Prednisone

After one year's use of beclomethasone dipropionate aerosol, 43 of 61 asthmatic patients who were originally dependent on oral corticosteroids were able to reduce and 38 to completely eliminate use of oral corticosteroids. Most patients maintained or improved their pulmonary functions. Exacerbation of rhinitis during oral corticosteroid withdrawal and emergence of nasal polyps were problems for 25 patients. Exacerbation of asthma with upper respiratory infection was an important event: 21 patients required supplemental oral corticosteroids to control asthma. Oral candidiasis occurred in only three patients.

Topics: Administration, Oral; Aerosols; Asthma; Beclomethasone; Humans; Nasal Polyps; Pharyngitis; Prednisone; Respiratory Function Tests; Rhinitis; Substance Withdrawal Syndrome

A prospective study of forty adult asthmatic patients attending two chest clinics in the City of Liverpool was undertaken. All patients had reversible airways obstruction and were under treatment with either beclomethasone dipropionate or sodium cromoglycate. Satisfactory symptomatic control was achieved in both groups of patients on a subjective basis, but there was a statistically significant (P less than 0-001) reduction in the number of admissions to hospital in the treatment year compared to the preceding 12 months in the beclomethasone aerosol group. No increased incidence of lower respiratory tract infections or non-specific sore throats was found in either group studied. No cases of clinical oral Candida infection occurred in the beclomethasone aerosol treated patients. It is concluded that beclomethasone dipropionate in aerosol form is not only a safe and effective method for symptomatic control of adult bronchial asthma but is also economically worthwhile as a means of reducing hospital admissions in this vulnerable group of patients.

Topics: Adult; Aerosols; Asthma; Beclomethasone; Candidiasis, Oral; Cromolyn Sodium; Female; Hospitalization; Humans; Lung Diseases; Male; Middle Aged; Pharyngitis; Prospective Studies; Respiratory Tract Infections

Topics: Beclomethasone; Chronic Disease; Drug Tolerance; Humans; Laryngitis; Otorhinolaryngologic Diseases; Paranasal Sinus Diseases; Pharyngitis; Rhinitis, Allergic, Seasonal

Orally inhaled and nasally exhaled beclomethasone diproprionate (b.d.) under increased nasopharyngeal pressure was found beneficial in ameliorating symptoms of allergic nasopharyngitis. The most spectacular help was obtained by patients suffering from sinus headache. This treatment also was found to avert the flaring up of rhinitis, an occasional "unmasking" effect of orally inhaled b.d.

Topics: Adolescent; Adult; Aged; Beclomethasone; Child; Child, Preschool; Drug Evaluation; Female; Humans; Hypersensitivity; Male; Middle Aged; Nasopharyngitis; Pharyngitis